Midfielder Theodore Whitmore hit a fine long-range double as Tranmere bounced back from Saturday's amazing home defeat by Bradford in style.
Rovers went down 5-4 to the Bantams at Prenton Park, but Jamaican international Whitmore helped ease any lingering disappointment with superb goals either side of the break.
Whitmore, who was boss Brian Little's first signing for Tranmere, fired the opener in off the bar from 20 yards after 15 minutes.
The strike was made possible by former Liverpool man Jason McAteer's quick free-kick down the left that was turned into Whitmore's path by Iain Hume.
And after Huddesfield's Pawel Abbott leveled with an equally impressive long-range effort, Whitmore struck again from distance by lashing home Ryan Taylor's centre on 61 minute from the left edge of the box.
Minutes later Whitmore could have completed an outstanding hat-trick but Town keeper Hume parried another blockbuster after he was put clear by striker Chris Dagnall.
Dagnall then sealed victory by prodding home from close range soon after when Taylor's corner from the right lead to goalmouth scramble.
There was a suspicion of hand ball against Huddersfield Efe Sodje during the incident but Glocester-based referee Steve Tanner waived a play on with Dagnell eventually taking a full advantage.
In the closing stages Huddersfield piled on the pressure but Tranmere's defence held firm.
They did, however, have a close escape two minutes from time when midfielder Chris Brandon's mis-hit shot from close range hit the outside of the post from Tony Carss' cross.